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NEW QUESTION: 1
Gene therapy offers a new treatment paradigm for curing human disease. Rather than altering the disease phenotype by using agents that interact with gene products, or are themselves gene products, gene therapy can theoretically modify specific genes resulting in disease cure following a single administration.
Initially gene therapy was envisioned for the treatment of genetic disorders, but is currently being studied for use with a wide range of diseases, including cancer, peripheral vascular disease, arthritis, Neurodegenerative disorders and other acquired diseases.
Certain key elements are required for a successful gene therapy strategy. The most elementary of these is that the relevant gene be identified and cloned. Upon completion of the Human Genome Project, gene availability will be unlimited. Once identified and cloned, the next consideration must be expression of the gene. Questions pertaining to the efficiency of gene transfer and gene expression remain at the forefront of gene therapy research, with current debates revolving around the transfer of desired genes to appropriate cells, and then to obtaining sufficient levels of expression for disease treatment. With luck, future research on gene transfer and tissue-specific gene expression will resolve these issues for the majority of gene therapy protocols.
Other important considerations for a gene therapy strategy include a sufficient understanding of the pathogenesis of the targeted disorder, potential side effects of the gene therapy treatment, and a more in depth understanding of the target cells which are to receive gene therapy.
Gene transfer vector is the mechanism by which the gene is transferred into a cell. Currently there are at least 150 clinical gene therapy protocols worldwide. Since the approval process for these protocols is not as public outside the U.S., it is difficult to ascertain the exact number of worldwide protocols. As of December 1995, 1024 patients had been treated with either a gene transfer or gene therapy protocol.
Much controversy exists regarding how many of these patients have benefited from their gene therapy, and no one has yet been cured.
Public controversy in the field of human gene therapy is driven by several factors. Ordinary citizens as well as scientists easily understand the enormous potential of gene therapy, but the former may not appreciate all the pitfalls and uncertainly that lie in the immediate future. The financial interests of biotechnology firms and, some have asserted the career interests of some gene therapists have encouraged extravagant, or at least verily optimistic public statements about contemporary gene therapy. In spite of the proliferation of protocols, the actual number of patients treated remains small, and only one genuinely controlled study of human gene therapy has been published as of this date The primary function of the fifth paragraph is to
A. Identify problems
B. Warn of consequences
C. Explain effects
D. Recommend actions
E. Evaluate solutions
Answer: A
Explanation:
Explanation/Reference:
Explanation:
The best answer is C.
The fifth paragraph is devoted to identifying various problems in the field today, such as the exaggerated claims made by biotechnological firms with vested financial interests.
NEW QUESTION: 2
A company runs multiple Windows virtual machines (VMs) in Azure.
The IT operations department wants to apply the same policies as they have for on-premises VMs to the VMs running in Azure, including domain administrator permissions and schema extensions.
You need to recommend a solution for the hybrid scenario that minimizes the amount of maintenance required.
What should you recommend? To answer, select the appropriate options in the answer area.
NOTE: Each correct selection is worth one point.
Answer:
Explanation:
Explanation:
Box 1: Join the VMs to a new domain controller VM in Azure
Azure provides two solutions for implementing directory and identity services in Azure:
(Used in this scenario) Extend your existing on-premises Active Directory infrastructure to Azure, by deploying a VM in Azure that runs AD DS as a Domain Controller. This architecture is more common when the on-premises network and the Azure virtual network (VNet) are connected by a VPN or ExpressRoute connection.
Use Azure AD to create an Active Directory domain in the cloud and connect it to your on-premises Active Directory domain. Azure AD Connect integrates your on-premises directories with Azure AD.
Box 2: Set up VPN connectivity.
This architecture is more common when the on-premises network and the Azure virtual network (VNet) are connected by a VPN or ExpressRoute connection.
References:
https://docs.microsoft.com/en-us/azure/architecture/reference-architectures/identity/
NEW QUESTION: 3
What does a comma accomplish when it is used in a SIP Dial Rule pattern that is associated with a Cisco 9971 IP Phone that is registered to Cisco Unified Communications Manager?
A. It is a delimiter and has no significant dialing impact.
B. It is an obsolete parameter and will be ignored.
C. It inserts a 500-millisecond pause between digits.
D. It causes the phone to generate a secondary dial tone.
E. It indicates a timeout value of 5000 milliseconds.
Answer: D
Explanation:
Comma is accepted in speed dial as delimiter and pause. -Comma used to delineate dial string, FAC, CMC, and post connect digits For post connect digits, commas insert a 2 second delay Commas may be duplicated to create longer delays
NEW QUESTION: 4
LAW1という名前のAzure Log Analyticsワークスペースを含むSub1という名前のAzureサブスクリプションがあります。
Windows Server 2016を実行し、LAW1に登録されている500個のAzure仮想マシンがあります。
システム更新評価ソリューションをLAW1に追加する予定です。
System Update Assessment関連のログは、100台の仮想マシンからのみLAW1にアップロードされるようにする必要があります。
順番に実行する必要がある3つのアクションはどれですか？回答するには、適切なアクションをアクションのリストから回答エリアに移動し、正しい順序に並べます。
Answer:
Explanation:
Explanation
References:
https://docs.microsoft.com/en-us/azure/azure-monitor/insights/solution-targeting
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